Decitabine + Venetoclax versus Intensive Chemotherapy for Patients with Relapsed/Refractory AML: A Propensity Score–Matched Analysis
The efficacy of 10-day decitabine plus venetoclax is comparable to intensive chemotherapy regimens as salvage therapy in younger patients with relapsed/refractory AML, and is an appropriate bridge to allogeneic stem-cell transplantation.
Escalated Dosing Schedules of CC-486 Effective for Patients Experiencing First AML Low Blast Count Relapse
For patients with AML in the QUAZAR AML-001 trial who relapsed with 5% to 15% blasts on-study, an escalated 21-day CC-486 (oral azacitidine) dosing regimen was well-tolerated and restored remission in approximately 25% of patients.
Gilteritinib + Azacitidine or Azacitidine Alone in Patients with Newly Diagnosed, FLT3-Mutated Acute Myeloid Leukemia
A study comparing gilteritinib + azacitidine with azacitidine alone in patients with newly diagnosed, FLT3-mutated AML showed no new safety signals associated with gilteritinib. The safety cohort showed a composite response rate of 67% for gilteritinib + azacitidine.
Comparative Effectiveness of Glasdegib or Venetoclax in Combination with Low-Dose Cytarabine Using Simulated Treatment Comparisons
Adjusted simulated treatment comparisons showed that the overall survival hazard ratios favored glasdegib plus low-dose cytarabine (LDAC) over venetoclax plus LDAC numerically, but not statistically.
Phase 1b/2 Study of Ivosidenib with Venetoclax ± Azacitidine in IDH1-Mutated Hematologic Malignancies
This study of 19 patients with IDH2-mutated acute myeloid leukemia indicates that a combination of the IDH2 inhibitor ivosidenib combined with venetoclax with or without azacitidine is effective and well-tolerated, warranting further study.
Safety and Efficacy of Decitabine + Ipilimumab in Relapsed/Refractory MDS/AML in Posttransplant or Transplant-Naïve Settings
In this study, in patients with relapsed/refractory or secondary myelodysplastic syndromes (MDS)/acute myeloid leukemia (AML), decitabine + ipilimumab exhibited encouraging clinical activity, with an anticipated adverse event profile.
The First-in-Class Anti-CD47 Antibody Magrolimab + Azacitidine Is Well-Tolerated and Effective in Patients with AML
This phase 1b study demonstrated that adding the novel macrophage-targeting immunotherapy magrolimab to azacitidine is well-tolerated and effective for treating patients with AML who are unfit for chemotherapy.
Venetoclax Added to Cladribine plus Low-Dose Ara-C Alternating with 5-Azacitidine in Older Patients with Newly Diagnosed Acute Myeloid Leukemia
Venetoclax added to the low-intensity backbone of cladribine plus low-dose cytarabine (Ara-C) alternating with 5-azacitidine was an effective regimen that was well-tolerated among patients with acute myeloid leukemia.
MBG453 in Combination with Hypomethylating Agents in Patients with High-Risk Myelodysplastic Syndrome or Acute Myeloid Leukemia
MBG453 combined with decitabine or azacitidine was safe and well-tolerated by patients with myelodysplastic syndrome or acute myeloid leukemia. Both combinations showed encouraging antileukemic activity and response rates.
Among patients with relapsed/refractory acute myeloid leukemia, CPX-351 plus 7 days of venetoclax was tolerable and demonstrated encouraging activity.