Matthew P. Mitchell, PharmD, MBA
Manager of Pharmacy Services, SelectHealth, Murray, Utah
Authored Items
Review of Ribociclib for Advanced Hormone Receptor–Positive Breast Cancer
Outside of initial clinical trials, few tools are available to assess the real-world impact of breast cancer on patients. In a research letter published in February 2017 in the Journal of the American Medical Association, the authors compared the impact of several new cancer drugs on progression-free survival (PFS) with their impact on the patient’s quality of life and annual cost.3
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The recent FDA approval of single-agent carfilzomib (Kyprolis) adds to the armamentarium of agents for the treatment of relapsed and refractory multiple myeloma. Carfilzomib was approved based on an open-label, single-arm study of single-agent carfilzomib after the failure of at least 2 previous therapies. Within the inclusion criteria, the subjects were required to have failed bortezomib. Although bortezomib and carfilzomib are both proteasome inhibitors, carfilzomib selectively and irreversibly binds to its target, which results in sustained proteasome inhibition that is absent of off-target effects relative to bortezomib.1,2 Read More ›
Web Exclusives
The recent FDA approval of single-agent carfilzomib (Kyprolis) adds to the armamentarium of agents for the treatment of relapsed and refractory multiple myeloma. Carfilzomib was approved based on an open-label, single-arm study of single-agent carfilzomib after the failure of at least 2 previous therapies. Within the inclusion criteria, the subjects were required to have failed bortezomib. Although bortezomib and carfilzomib are both proteasome inhibitors, carfilzomib selectively and irreversibly binds to its target, which results in sustained proteasome inhibition that is absent of off-target effects relative to bortezomib.1,2 Read More ›