Stay Up to Date
Breaking News,
Updates, & More
Click Here to

Lenalidomide Maintenance Therapy Benefits Patients With Multiple Myeloma

TOP - Daily published on May 15, 2012 in Skin Cancer

Oftentimes, patients with multiple myeloma experience disease progression even after receiving a stem cell transplant. However, according to a recent study, a new long-term therapy, lenalidomide, can be used after transplantation to slow down the progression of the disease.

The clinical trial, published recently in the New England Journal of Medicine, assessed the effect of maintenance lenalidomide therapy on disease-free survival after transplant. Lenalidomide is an oral drug that can be taken for many months or even years. Thomas Shea, MD, director of the Bone Marrow and Stem Cell Transplant Program and associate director for outreach programs at University of North Carolina Lineberger, and Don Gabriel, MD, professor of medicine in the division of hematology/oncology, were coauthors of the study.

The phase 3 study demonstrated that lenalidomide maintenance therapy is associated with significant improvements in patients who have undergone a stem cell transplant due to newly diagnosed myeloma. The probability of disease-free survival (the primary end point) for 3 years was 59% in the lenalidomide group, compared with 35% in the placebo group.

“The results of this trial will change our treatment of multiple myeloma patients,” said Shea. “While lenalidomide has some risks, including an increase in people developing second cancers, it generally appears to be well-tolerated when given long-term and was associated with a delay in time to progression of the myeloma as well as an improvement in overall survival” he added.

Source: UNC.

Related Items
Libtayo (Cemiplimab-rwlc), a PD-1 Inhibitor, First Drug Approved by the FDA for Patients with Advanced Cutaneous Squamous-Cell Carcinoma
Loretta Fala, Medical Writer
2019 Fourth Annual Oncology Guide to New FDA Approvals published on June 5, 2019 in FDA Updates, Skin Cancer
Potential New Approach to Treat Melanoma
Phoebe Starr
TOP - October 2014, Vol 7, No 4 published on October 30, 2014 in Skin Cancer
Combination of BRAF and MEK Inhibitors Improves Survival in Advanced Melanoma
Phoebe Starr
TOP - October 2014, Vol 7, No 4 published on October 30, 2014 in Skin Cancer
Immunotherapies Take Center Stage in Melanoma
F. Stephen Hodi, Jr, MD, Lynn M. Schuchter, MD, Mario Sznol, MD, Kim A Margolin, MD
TOP - August 2013 VOL 6, NO 3 published on September 5, 2013 in Skin Cancer
Recent Advances in the Treatment of Metastatic Melanoma
Megan Hagerty, PharmD, BCOP
TOP - Special Issue May 2012, Vol 5, No 3 published on May 24, 2012 in Skin Cancer
Vismodegib: A New Treatment Option for Basal Cell Carcinoma
Rhonda Williams
TOP - April 2012, Vol 5, No 2 published on April 30, 2012 in Skin Cancer
Can Aspirin Ward Off Melanoma?
TOP - Daily published on July 13, 2011 in Skin Cancer
Peptide Vaccine Doubles Clinical Response Rate in Advanced Melanoma
TOP - Daily published on June 3, 2011 in Skin Cancer
Ipilimumab (Yervoy) Is First Melanoma Drug Approved in a Decade
Christin Melton
TOP - March/April 2011, VOL 4, NO 2 published on April 28, 2011 in Skin Cancer
Last modified: July 22, 2021