Colorectal Cancer

For patients with a past history or family history of colorectal cancer, annual fecal immunochemical tests (FITs) detect neoplasias sooner than scheduled 10-year colonoscopies, according to a new study published in the December issue of Gastroenterology. For patients with FIT-positive results, diagnosis was made sooner by 25 months for cancer and by 24 months for advanced adenomas.
 

Pharmacogenomics is the study of the role of inherited and acquired genetic variation in drug response.1 A focus of research in recent years on genome-wide association studies ultimately may help identify patient- and/or cancer-specific biomarkers that will facilitate optimization of drug therapy including guiding drug selection, dose, and treatment duration.2 The identification of the role of KRASmutations in select patients with colorectal cancer (CRC) who are candidates for epidermal growth factor receptor (EGFR) in hibitors is one example of the clinical a

SALT LAKE CITY—Reliable tests are sorely needed to help determine the best dose regimen before chemotherapy to minimize toxicities for patients with metastatic colon cancer, according to a talk given at the annual meeting of the Hematology/Oncology Pharmacy Association.

SAN FRANCISCO—For patients with colorectal cancer (CRC), advances in molecular profiling have led to an ex - plosion in novel agents specific for targets above and beyond the epidermal growth factor receptor (EGFR). Joseph Tabernero, MD, director of clinical research at Vall d’Hebron Institute of Oncology in Barcelona, Spain, previewed the future of treatment for CRC at the 2011 Gastrointestinal Cancers Symposium.

Updated analysis of disease-free survival (DFS) in the NO16968 trial confirms a survival benefit with the addition of oxaliplatin in adjuvant treatment of stage III colorectal cancer. The study compared XELOX (capecitabine plus oxaliplatin) versus bolus 5-fluorouracil/leucovorin (5-FU/LV) in 1886 patients with resected stage III colon cancer, and the updated analysis was based on a median follow-up of 7 years.

In recent years, researchers have considered a potential link between beta-blockers and a decreased risk of cancer. This theory stems from the fact that beta-blockers inhibit the actions of the stress hormone norepinephrine. This, along with studies that found norepinephrine can promote the growth and spread of cancer cells, led researchers to reason that the beta-blockers could have anticancer properties.

However, a recent study published early online in Cancer revealed that the use of beta-blockers showed no reduction of colorectal cancer risk.

The clinical response to regorafenib does not depend on tumor mutations. Among patients with metastatic colorectal cancer who participated in the phase 3 CORRECT (Colorectal Cancer Treated With Regorafenib or Placebo After Failure of Standard Therapy) study, an analysis of tumor specimens for KRAS and PIK3CA mutations did not predict clinical benefit in the patients assigned to regorafenib compared with placebo, said Michael Jeffers, PhD. He presented the results of the study at the 2013 Gastrointestinal Cancers Symposium.
Results of a phase 3 study of an investigational monoclonal antibody, MABp1 (Xilonix; XBiotech), evaluated for cachexia in metastatic colorectal cancer (CRC), revealed a surprising finding: patients in the experimental arm showed a trend toward increased overall survival (an end point difficult to reach in any treatment-refractory cancer), with pharmacodynamics activity consistent with this result, investigators reported at the 2015 Gastrointestinal Cancers Symposium, held in San Francisco, CA.
The WCGIC chairperson, professor Eric Van Cutsem, MD, PhD, heads the Division of Digestive Oncology at University Hospitals Leuven and KU Leuven, Leuven, Belgium. He describes the difference between left- and right-sided colon cancers in terms of prognosis and response to therapy.
Over­whelming evidence supports a chemo­preventive benefit of aspirin on colorectal cancer (CRC), and a potential effect on other cancers and cardiovascular risk.
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