TOP - September 2020 Vol 13, No 5

The combination of carfilzomib (Kyprolis) with lenalidomide (Revlimid) and dexamethasone (KRd) as induction therapy does not improve outcomes in patients newly diagnosed with multiple myeloma compared with the current standard of care with bortezomib (Velcade), lenalidomide, and dexamethasone (VRd).
Cellular therapy is becoming an attractive option for heavily pretreated patients with relapsed or refractory multiple myeloma. According to data presented at the ASCO 2020 virtual annual meeting, 2 chimeric antigen receptor (CAR) T-cell drugs have generated impressive rates of response that are sustainable.
During a recent Association for Value-Based Cancer Care (AVBCC) webcast, titled Potential for Cancer Agents in the Treatment of COVID-19, a panel of healthcare experts discussed the latest studies investigating the use of anti-cancer therapies as treatments for COVID-19.
New research highlights the importance of germline analysis in the identification of germline alterations for cancer treatment. According to a large analysis presented at the ASCO 2020 virtual annual meeting, nearly 9% of patients with advanced cancer harbor a targetable germline variant.
Cemiplimab-rwlc (Libtayo), a new PD-1 inhibitor, has transformed the treatment of advanced cutaneous squamous-cell carcinoma (CSCC), significantly extending survival for patients.
According to results of the phase 3 multinational ADAURA clinical trial, treatment with osimertinib in the adjuvant setting significantly improves disease-free survival in patients with localized non–small-cell lung cancer (NSCLC) with EGFR mutation.
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