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What important changes in recent years do those treating patients with lymphoma need to keep in focus? Those treating newly diagnosed T-cell lymphomas, according to Owen A. O’Connor, MD, PhD, professor of medicine and pharmacology and chief of the division of hematologic malignancies and medical oncology at the New York University Langone Medical Center Cancer Institute in New York City, need to enroll their patients in clinical trials of combinations of newer agents, and those treating mantle cell lymphomas can consider upfront autologous stem cell transplant (SCT).

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Deborah Armstrong, MD

SAN FRANCISCO—Poly(ADP-ribose) polymerase (PARP) inhibitors are showing impressive potency against ovarian cancer in early clinical trials, according to Deborah Armstrong, MD, an associate professor of oncology, gynecology, and obstetrics at Johns Hopkins University, Baltimore, Maryland.

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MILAN—Breakthrough pain in cancer patients can be managed easily and effectively with fentanyl pectin nasal spray (FPNS), according to new data.

FPNS can be easily titrated to an effective dose and there is little need for rescue medication, according to David Brooks, MD, of Chesterfield and North Derbyshire Royal Hospital NHS Trust in Chesterfield, United Kingdom.

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MILAN—Sexual issues related to cancer and its treatment are substantial—and do not seem to be resolving with the use of new molecular targeted agents instead of endocrine therapy and chemotherapy. This conclusion can be drawn from two studies presented by investigators from Argentina and France.

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MILAN—Prolonging chemotherapy until disease progression improves progression- free survival (PFS) and overall survival (OS) in patients with metastatic breast cancer (MBC), according to a systematic analysis conducted in Italy.

The findings address an important debate in oncology, said Alessandra Gennari, MD, of Ospedali Galliera in Genova. “In metastatic breast cancer there is substantial controversy over how long chemotherapy should be continued in the absence of significant toxicity, after the achievement of disease control,” said Gennari.

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Most people understand the importance of saving for retirement and want to save more, but do not know where to begin. Furthermore, the economic downturn has resulted in fewer people putting away money for retirement.

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STOCKHOLM—New data undermine the widely held notion that the greater likelihood of cancer seen in diabetic patients on insulin therapy increases with longer insulin use.

In fact, the findings, reported at the 46th European Association for the Study of Diabetes meeting, show that the increased cancer risk in diabetes drops substantially with long-term insulin use.

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Adjuvant trastuzumab treatment may be beneficial for women with small human epidermal growth factor receptor 2 (HER2)-positive breast tumors, according to a review by British researchers.
 
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Approximately half of colorectal and cervical cancer cases and one third of breast cancer cases are still diagnosed at a late stage of disease, according to a Surveillance Summary released by the US Centers for Disease Control and Prevention (CDC) in the November 26 issue of Morbidity and Mortality Weekly Report.
 
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Endosonography combined with surgical staging has greater sensitivity for detecting mediastinal nodal metastases, according to results of a randomized, controlled trial published in the November 24 issue of JAMA.
 
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