Breast Cancer
SALT LAKE CITY—Bisphosphonates may have a role as an adjuvant breast cancer treatment, cisplatin-based neoadjuvant chemotherapy should be considered for treating bladder cancer, and dose-dense chemotherapy may add benefit for patients with pediatric Ewing sarcoma, according to 3 presentations at the “Controversies in Care” session at the annual meeting of the Hematology/Oncology Pharmacy Association.
Bisphosphonates in Breast Cancer
Read More ›
The US Food and Drug Administration (FDA) has approved Inform Dual ISH (Ventana Medical Systems), a genetic test that allows for measurement of the number of copies of the HER2 gene in tumor tissue. This method of identification of women with breast cancer who are HER2-positive pinpoints who is, and who is not, a candidate for Herceptin (trastuzumab).
Read More ›
Blocking miR-21 overexpression was found to retrieve trastuzumab sensitivity in trastuzumab-resistant breast cancer cells, in a study of cell lines derived from HER2-postive breast carcinomas. This theory was derived from identification of overexpression of miR-21 in HER-positive, trastuzumab-resistant cells. The researchers also found that miR-21 upregulation in trastuzumab-resistant cells led to PTEN reduction.
Read More ›
The evidence backing the use of myeloid growth factors in patients at high risk for febrile neutropenia is solid, according to Jeffrey Crawford, MD, of Duke Cancer Institute, Durham, North Carolina.
Myeloid growth factors are the primary means of preventing chemotherapy-induced neutropenia. This often leads to febrile neutropenia, which can be fatal in 10% of patients, according to a database of more than 40,000 individuals. Concerns recently have been raised, however, that their use is associated with myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML).
Read More ›