Supportive Care

ANAHEIM—Hypersensitivity or infusion reactions to chemotherapy agents or monoclonal antibodies can be lifethreatening but often can be managed with premedications or titration of infusion rates, said Catherine Christen, PharmD, at the 45th American Society of Health-System Pharmacists Midyear Clinical Meeting & Exposition.

Medications associated with infusion reactions are platinum agents, taxanes, liposomal doxorubicin, etoposide, and monoclonal antibodies. Hypersensitivity reactions can be either allergic (IgE-mediated) or nonallergic (anaphylactoid).
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ANAHEIM—Hypersensitivity or infusion reactions to chemotherapy agents or monoclonal antibodies can be life-threatening but often can be managed with premedications or titration of infusion rates to allow continuance of therapy, said Catherine Christen, PharmD, at the 45th American Society of Health-System Pharmacists Midyear Clinical Meeting & Exposition.

The evidence backing the use of myeloid growth factors in patients at high risk for febrile neutropenia is solid, according to Jeffrey Crawford, MD, of Duke Cancer Institute, Durham, North Carolina.

Impaired Hydroxylation of 5-Methylcytosine in TET2-Mutated Myeloid Malignancies
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Serum Albumin Affects Methotrexate Level Variability and Methotrexate Toxicity
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In a multicenter, randomized, phase 2/3 trial, the 4-drug combination oxaliplatin/irinotecan/fluorouracil/leucovorin (FOLFIRINOX) prolonged median overall and progression-free survival and increased the overall response rate compared with gemcitabine, the reference standard, for patients with metastatic pancreatic adenocarcinoma and good performance status (0-1). However, the combination regimen was associated with more adverse events, especially febrile neutropenia, and a decrease in quality of life.

Cancer treatment–induced diarrhea (CTID) occurs in 50% to 80% of patients receiving chemo therapy and 50% of patients undergoing radiotherapy. Older patients, women, patients on an irinotecan-containing regimen, and patients treated in the adjuvant setting are at higher risk of CTID, reported Kelly Markey, PharmD, BCOP. Markey is a clinical pharmacist with the gastrointestinal tumor program at Moffitt Cancer Center in Tampa, Florida, and discussed CTID at the annual meeting of the Hematology/Oncology Pharmacy Association.

The median age for someone to receive a cancer diagnosis is 67 years according to the Surveillance, Epidemiology, and End Results database and even higher for certain malignancies. For example, many gastrointestinal cancers are diagnosed in septuagenarians. Read More ›