ASCO GU Cancer Highlights

The addition of sacituzumab govitecan (Trodelvy), an antibody–drug conjugate, to the PD-1 inhibitor pembrolizumab (Keytruda) showed encouraging antitumor activity in checkpoint inhibitor–naïve patients with metastatic urothelial cancer, according to an analysis of the results of cohort 3 from the phase 2 TROPHY-U-01 clinical trial, which were presented at the 2022 American Society of Clinical Oncology Genitourinary Cancers Symposium by Petros Grivas, MD, PhD, Clinical Director, Genitourinary Cancers Program, University of Washington School of Medicine, Seattle; and Associate Professor, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle. Read More ›

Continuous treatment with the androgen receptor inhibitor enzalutamide (Xtandi) in combination with docetaxel significantly improved progression-free survival (PFS) compared with placebo plus docetaxel in men with metastatic castration-resistant prostate cancer (mCRPC) whose disease progressed while receiving enzalutamide alone in the phase 3b PRESIDE clinical trial. Read More ›

Neoadjuvant therapy with enfortumab vedotin (Padcev) showed promising antitumor activity in patients with MIBC who were ineligible for cisplatin therapy, based on the preliminary findings for cohort H from the phase 1b/2 EV-103 clinical trial. Read More ›

Belzutifan, an oral, novel hypoxia-inducible factor (HIF)-2α inhibitor, showed encouraging activity as a single agent in heavily pretreated patients with advanced clear-cell renal-cell carcinoma (RCC) associated with von Hippel-Lindau (VHL) disease, as well as impressive tumor shrinkage when used in combination with cabozantinib (Cabometyx) in separate studies presented at the virtual 2021 ASCO Genitourinary Cancers Symposium. Read More ›

In patients with metastatic urothelial cancer who received previous therapy, as well as in cisplatin-ineligible patients with this cancer, enfortumab vedotin-ejfv (Padcev) improved overall survival (OS), according to new data presented at the virtual 2021 ASCO Genitourinary Cancers Symposium. Read More ›