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TOP - February 2016, Vol 9, No 1

The American Society of Health-System Pharmacists (ASHP) Foundation's Pharmacy Forecast, now in its fourth edition, serves to improve the effectiveness of leaders in hospital and health-system pharmacy practice. Read More ›

Conference News
Here is a review of study results of various medications being reported from different conferences. Read More ›

FDA News
Here is an overview of oncology medications that were recently approved by the U.S. Food and Drug Administration. Read More ›

LMWH Protocol for Thrombocytopenia Validated in Study
Guidelines for enoxaparin dose reduction when treating chemotherapy-induced thrombocytopenia (CIT) have been validated by a quality assessment study conducted at Memorial Sloan Kettering Cancer Center (MSKCC) in New York. Read More ›

Orlando, FL–New agents with novel targets have revolutionized management of chronic lymphocytic leukemia (CLL). However, all drugs have risks and benefits. At the 57th American Society of Hematology (ASH) Annual Meeting & Exposition, 3 separate presentations highlighted toxicity concerns related to idelalisib, ibrutinib, and venetoclax: hepatotoxicity with idelalisib, drug–drug interactions with ibrutinib, and the need for careful dosing at initiation of venetoclax. Read More ›

In the February issue of The Oncology Pharmacist, we feature a recent study that was presented at the 2015 Palliative Care in Oncology Symposium on aprepitant (Emend), a centrally acting neurokinin-1 antagonist indicated for patients with chemotherapy-induced nausea and vomiting. Read More ›

An open-label, randomized, phase 2 study evaluated the all-oral triplet combination of ixazomib (an orally administered proteasome inhibitor) plus cyclophosphamide (at 2 different doses) and low-dose dexamethasone (ICd) as a 12-month induction therapy in previously untreated, transplant-ineligible patients with multiple myeloma (MM). Read More ›

Presence of cytogenetic abnormalities (CAs) is considered to be an important prognostic factor in patients with multiple myeloma (MM), with some evidence suggesting that bortezomib-based combinations may overcome the poor prognosis associated with CAs, such as t(4;14), t(14;16), or deletion of 17p (del [17p]). Read More ›

San Antonio, TX–A scalp cooling system protects against chemotherapy-induced hair loss in patients with breast cancer, and contributes to their well-being. The effects of the DigniCap scalp cooling system in 110 patients were presented at the 2015 San Antonio Breast Cancer Symposium. Read More ›

Imatinib mesylate (IM) at 400 mg/day is the standard of care as first-line therapy in patients with newly diagnosed, chronic-phase chronic myeloid leukemia (CP-CML). Based on evidence that patients with high imatinib trough levels achieved higher rates of major molecular response (MMR), the randomized OPTIM-imatinib trial was conducted to evaluate the value of imatinib dose optimization according to imatinib Cmin levels in newly diagnosed patients with CP-CML. Read More ›

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