Clinical trial recruitment and retention remain challenges in the quest to bring innovative therapies to all patients in need. In oncology, therapies continue to evolve, yet researchers are frequently faced with low trial participation, particularly among minority groups. The Oncology Pharmacist (TOP) is dedicated to providing comprehensive information aimed at eliminating health disparities and improving access to therapies for people from all populations, including racial and ethnic minorities; people with limited access to healthcare due to lack of financial resources; and people living in rural communities.
This feature in TOP aims to provide ongoing lists of US-based phase 2 or 3 clinical trials that are actively recruiting. This issue is focused on cervical cancer, the January cancer awareness month. Healthcare practitioners may use this listing in discussions with their patients to encourage enrollment. As NCCN has stated, “The best management of any cancer patient is in a clinical trial.”
These clinical trial listings can be found at www.ClinicalTrials.gov.
- Hypofractionated Radiochemotherapy
- ClinicalTrials.gov identifier: NCT06331468
- Sponsor: Denise Fabian, University of Kentucky
- Interventions: cisplatin; radiation: intensity modulated radiation therapy; radiation: high-dose-rate brachytherapy
- Cervical Boost by Ablative Stereotactic Radiotherapy (SABR) vs Brachytherapy in Patients With Cervical Carcinoma
- ClinicalTrials.gov identifier: NCT06560697
- Sponsor: National Institute of Cancerología
- Collaborator: National Institute of Medical Sciences and Nutrition, Salvador Zubiran
- Use Misoprostol to Optimize Prevention of Cervical Cancer
- ClinicalTrials.gov identifier: NCT06669533
- Sponsor: Warner Huh, University of Alabama at Birmingham
- Collaborator: Cameroon Baptist Convention Health Core
- Phase II Trial Comparison of 3 vs 4 Fractions (BRACHY-FIT)
- ClinicalTrials.gov identifier: NCT07022470
- Sponsor: Elizabeth Kidd, Stanford University
- Hyaluronic Acid-based Gel Spacers in Gynecologic Malignancies
- ClinicalTrials.gov identifier: NCT07292818
- Sponsor: Shivani Sud, University of North Carolina Lineberger Comprehensive Cancer Center
- Collaborator: Teleflex
- Fenofibrate in Patients With Cervical Intraepithelial Neoplasia and Invasive Cervical Carcinoma
- ClinicalTrials.gov identifier: NCT06191133
- Sponsor: Lindsay Ferguson, Case Comprehensive Cancer Center
- Collaborator: University Hospitals Cleveland Medical Center
- Video-Based Patient Navigation to Support Cervical Cancer Screening Among Black Women (mNav)
- ClinicalTrials.gov identifier: NCT07011836
- Sponsor: ISA Associates, Inc.
- Collaborator: National Institute on Minority Health and Health Disparities
- Pembrolizumab for the Treatment of Cervical Intraepithelial Neoplasia
- ClinicalTrials.gov identifier: NCT04712851
- Sponsor: John A Glaspy, Jonsson Comprehensive Cancer Center
- Collaborator: Merck Sharp & Dohme LLC
- Study of Pembrolizumab and Lenvatinib in Metastatic and Recurrent Cervix Cancer (LenPem Cervix)
- ClinicalTrials.gov identifier: NCT06266338
- Sponsor: Jayanthi Lea, University of Texas Southwestern Medical Center
- Collaborator: Merck Sharp & Dohme LLC
- Unidos Contra el VPH (Unidos)
- ClinicalTrials.gov identifier: NCT06825689
- Sponsor: Jessica Calderon-Mora, University of Texas at Austin
- Collaborator: Texas Tech University Health Sciences Center, El Paso
- Emergency Department-based Cervical Cancer Screening Through Self-sampling
- ClinicalTrials.gov identifier: NCT07345897
- Sponsor: Beau Abar, University of Rochester
- Glutaminase Inhibition and Chemoradiation in Advanced Cervical Cancer
- ClinicalTrials.gov identifier: NCT05521997
- Sponsor: Julie K Schwarz, Washington University School of Medicine
- Collaborators: National Cancer Institute; Calithera Biosciences, Inc
- Accelerated Brachytherapy Forward Chemo Radiation Therapy (ABC-RT) for Locally-advanced Cervical Cancer
- ClinicalTrials.gov identifier: NCT06529809
- Sponsor: Jessika A Contreras, Washington University School of Medicine
- Collaborator: National Cancer Institute
- HPV DNA Vaccine Via Electroporation for HPV16 Positive Cervical Neoplasia
- ClinicalTrials.gov identifier: NCT04131413
- Sponsor: Kimberly Levinson, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
- Collaborator: National Cancer Institute
- Development of Systems and Education for Cervical Cancer Prevention (DOSE-CC)
- ClinicalTrials.gov identifier: NCT07226037
- Sponsor: Lunze Karsten, Boston Medical Center
- Collaborator: National Cancer Institute
- Circulating Human Papilloma Virus (HPV) DNA for the Screening and Surveillance of Gynecologic Cancers
- ClinicalTrials.gov identifier: NCT05606133
- Sponsor: Elena Pereira, Northwell Health
- Collaborator: Naveris
- A Clinical Trial to Investigate the Safety and Efficacy of Papillex® on Abnormal Cervical Cells Caused by HPV
- ClinicalTrials.gov identifier: NCT06979180
- Sponsor: Papillex Inc.
- Uniting Trusted Community Messengers to Improve Access to Cervical Cancer Screening in Rural North Carolina
- ClinicalTrials.gov identifier: NCT07294066
- Sponsor: Lisa Mansfield, University of North Carolina Lineberger Comprehensive Cancer Center
- Collaborator: National Institute on Minority Health and Health Disparities
- Biological Drivers of Cervical Cancer and Side Effects From Radiation Therapy
- ClinicalTrials.gov identifier: NCT07121543
- Sponsor: Jyoti Mayadev University of California, San Diego
- Collaborator: National Institute on Minority Health and Health Disparities
- Pembrolizumab and Lenvatinib in Advanced Cervical Cancer
- ClinicalTrials.gov identifier: NCT04865887
- Sponsor: Samir Khleif, Georgetown University
- Collaborator: Merck Sharp & Dohme LLC