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TOP - August 2017, Vol 10, No 3

New Drug Therapies for Relapsed or Refractory Multiple Myeloma
Although the 5-year survival rate for multiple myeloma is less than 50%, this type of cancer has witnessed a resurgence of drug therapies. Read More ›

Each year, >200,000 individuals in the United States are diagnosed with a primary or metastatic brain tumor. Primary brain tumors comprise approximately 40,000 of these diagnoses. Read More ›


Centers for Disease Control and Prevention Guidelines on Opioid Use for Cancer Pain
The United States may be in the midst of an opioid epidemic, but the undertreatment of pain remains an issue for patients with cancer. Read More ›

Prescription Drug Use High Among Survivors of Childhood Cancers
Childhood cancer therapy can be a double-edged sword; it often leads to a cure, but long after treatment ends, some survivors have treatment-related side effects. Read More ›

The power to fight a virtually infinite array of pathogens is one of the hallmarks of the human immune system, and random diversity is its secret weapon. Read More ›

Adding the investigational drug indoximod, an indoleamine 2,3-dioxygenase (IDO) pathway inhibitor, to the checkpoint inhibitor pembrolizumab led to higher response rates in patients with advanced melanoma than what is reported with pembrolizumab monotherapy, Read More ›

Although transplantation offers cures or durable remissions for malignancies, relapse is a frequent occurrence in many diseases, and remains a major cause of mortality. Read More ›

Despite significant progress in stem-cell transplantations over the past decade, graft-versus-host disease (GVHD) remains the leading cause of nonrelapse death in this patient population. Read More ›


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